{"id":105,"date":"2017-11-27T16:38:48","date_gmt":"2017-11-27T13:38:48","guid":{"rendered":"http:\/\/spiporz.ru\/fabri1\/?page_id=105"},"modified":"2017-11-27T19:23:14","modified_gmt":"2017-11-27T16:23:14","slug":"tserebrovaskulyarnaya-sistema","status":"publish","type":"page","link":"https:\/\/spiporz.ru\/fabry\/tserebrovaskulyarnaya-sistema\/","title":{"rendered":"\u0426\u0435\u0440\u0435\u0431\u0440\u043e\u0432\u0430\u0441\u043a\u0443\u043b\u044f\u0440\u043d\u0430\u044f \u0441\u0438\u0441\u0442\u0435\u043c\u0430"},"content":{"rendered":"<p>\u0423\u0441\u0442\u0430\u043d\u043e\u0432\u043b\u0435\u043d\u043e, \u0447\u0442\u043e \u0434\u043e 4,9% \u043c\u0443\u0436\u0447\u0438\u043d \u0438 2,4% \u0436\u0435\u043d\u0449\u0438\u043d \u0432 \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0435 18\u201355 \u043b\u0435\u0442, \u0443 \u043a\u043e\u0442\u043e\u0440\u044b\u0445 \u0440\u0430\u0437\u0432\u0438\u043b\u0441\u044f \u0438\u043d\u0441\u0443\u043b\u044c\u0442 \u043d\u0435\u0443\u0442\u043e\u0447\u043d\u0435\u043d\u043d\u043e\u0433\u043e \u0433\u0435\u043d\u0435\u0437\u0430, \u043d\u0430 \u0441\u0430\u043c\u043e\u043c \u0434\u0435\u043b\u0435 \u043c\u043e\u0433\u043b\u0438 \u0441\u0442\u0440\u0430\u0434\u0430\u0442\u044c \u043d\u0435\u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u0439 \u0431\u043e\u043b\u0435\u0437\u043d\u044c\u044e \u0424\u0430\u0431\u0440\u0438. (* 1) \u0418\u043d\u0441\u0443\u043b\u044c\u0442 \u2013 \u043e\u0434\u043d\u0430 \u0438\u0437 \u043e\u0441\u043d\u043e\u0432\u043d\u044b\u0445 \u043f\u0440\u0438\u0447\u0438\u043d \u0441\u043c\u0435\u0440\u0442\u0438 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0431\u043e\u043b\u0435\u0437\u043d\u044c\u044e \u0424\u0430\u0431\u0440\u0438. (* 2)<\/p>\n<p>\u0426\u0435\u0440\u0435\u0431\u0440\u043e\u0432\u0430\u0441\u043a\u0443\u043b\u044f\u0440\u043d\u044b\u0435 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f \u0440\u0430\u0437\u0432\u0438\u0432\u0430\u044e\u0442\u0441\u044f \u0443 \u043c\u0443\u0436\u0447\u0438\u043d \u0432 \u043d\u0430\u0447\u0430\u043b\u0435 3 \u0434\u0435\u043a\u0430\u0434\u044b \u0436\u0438\u0437\u043d\u0438, \u0430 \u0443 \u0436\u0435\u043d\u0449\u0438\u043d \u2013 \u0432 \u043d\u0430\u0447\u0430\u043b\u0435 4 \u0434\u0435\u0441\u044f\u0442\u0438\u043b\u0435\u0442\u0438\u044f \u0436\u0438\u0437\u043d\u0438; (* 3) \u043f\u043e \u043d\u0435\u043a\u043e\u0442\u043e\u0440\u044b\u043c \u043e\u0446\u0435\u043d\u043a\u0430\u043c, \u0432\u0435\u0440\u043e\u044f\u0442\u043d\u043e\u0441\u0442\u044c \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044f \u0438\u043d\u0441\u0443\u043b\u044c\u0442\u0430 \u0443 \u043c\u0443\u0436\u0447\u0438\u043d \u0441 \u0431\u043e\u043b\u0435\u0437\u043d\u044c\u044e \u0424\u0430\u0431\u0440\u0438 \u0432 \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0435 25 \u043b\u0435\u0442 \u2013 44 \u0433\u043e\u0434\u0430 \u043f\u0440\u0438\u043c\u0435\u0440\u043d\u043e \u0432 12 \u0440\u0430\u0437 \u0432\u044b\u0448\u0435, \u0447\u0435\u043c \u0432 \u043e\u0431\u0449\u0435\u0439 \u043f\u043e\u043f\u0443\u043b\u044f\u0446\u0438\u0438 \u0442\u043e\u0433\u043e \u0436\u0435 \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430. (* 4)<\/p>\n<p>\u0426\u0435\u0440\u0435\u0431\u0440\u043e\u0432\u0430\u0441\u043a\u0443\u043b\u044f\u0440\u043d\u044b\u0435 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f \u0432\u043a\u043b\u044e\u0447\u0430\u044e\u0442:<\/p>\n<ul>\n<li>\u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u044f \u0431\u0435\u043b\u043e\u0433\u043e \u0432\u0435\u0449\u0435\u0441\u0442\u0432\u0430; (* 5; 6)<\/li>\n<li>\u0443\u0441\u0438\u043b\u0435\u043d\u0438\u0435 \u0440\u0435\u0433\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u043a\u0440\u043e\u0432\u043e\u0442\u043e\u043a\u0430 \u0433\u043e\u043b\u043e\u0432\u043d\u043e\u0433\u043e \u043c\u043e\u0437\u0433\u0430 \u0432 \u043f\u043e\u043a\u043e\u0435; (* 7)<\/li>\n<li>\u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u044f \u0432\u0435\u0440\u0442\u0435\u0431\u0440\u043e\u0431\u0430\u0437\u0438\u043b\u044f\u0440\u043d\u044b\u0445 \u0441\u043e\u0441\u0443\u0434\u043e\u0432; (* 6)<\/li>\n<li>\u0438\u0437\u0432\u0438\u0442\u043e\u0441\u0442\u044c \u0438 \u0440\u0430\u0441\u0448\u0438\u0440\u0435\u043d\u0438\u0435 \u043a\u0440\u0443\u043f\u043d\u044b\u0445 \u0441\u043e\u0441\u0443\u0434\u043e\u0432. (* 5; 6)<\/li>\n<\/ul>\n<div class=\"caption\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-106\" src=\"http:\/\/spiporz.ru\/fabri1\/wp-content\/uploads\/sites\/7\/2017\/11\/hcp_signs_mri_scans.jpg\" alt=\"\" width=\"591\" height=\"592\" srcset=\"https:\/\/spiporz.ru\/fabry\/wp-content\/uploads\/sites\/7\/2017\/11\/hcp_signs_mri_scans.jpg 591w, https:\/\/spiporz.ru\/fabry\/wp-content\/uploads\/sites\/7\/2017\/11\/hcp_signs_mri_scans-150x150.jpg 150w, https:\/\/spiporz.ru\/fabry\/wp-content\/uploads\/sites\/7\/2017\/11\/hcp_signs_mri_scans-300x300.jpg 300w\" sizes=\"auto, (max-width: 591px) 100vw, 591px\" \/>\u041c\u0420\u0422 \u0433\u043e\u043b\u043e\u0432\u043d\u043e\u0433\u043e \u043c\u043e\u0437\u0433\u0430: (a) \u0438\u043d\u0444\u0430\u0440\u043a\u0442 \u043c\u043e\u0437\u0436\u0435\u0447\u043a\u0430; (b) \u043c\u043d\u043e\u0436\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0435 \u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u044f \u0431\u0435\u043b\u043e\u0433\u043e \u0432\u0435\u0449\u0435\u0441\u0442\u0432\u0430 \u0432 \u043f\u043e\u043b\u0443\u0448\u0430\u0440\u0438\u044f\u0445 \u0433\u043e\u043b\u043e\u0432\u043d\u043e\u0433\u043e \u043c\u043e\u0437\u0433\u0430; (c) \u0441\u0438\u043c\u043c\u0435\u0442\u0440\u0438\u0447\u043d\u044b\u0439 \u0432\u044b\u0441\u043e\u043a\u0438\u0439 \u0441\u0438\u0433\u043d\u0430\u043b \u043e\u0431\u043b\u0430\u0441\u0442\u0438 \u043f\u043e\u0434\u0443\u0448\u043a\u0438 \u0442\u0430\u043b\u0430\u043c\u0443\u0441\u0430; (d) \u0440\u0430\u0441\u0448\u0438\u0440\u0435\u043d\u043d\u044b\u0435 \u0438 \u0438\u0437\u0432\u0438\u0442\u044b\u0435 \u0441\u043e\u0441\u0443\u0434\u044b. \u0412\u043e\u0441\u043f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0438\u0442\u0441\u044f \u0441 \u0440\u0430\u0437\u0440\u0435\u0448\u0435\u043d\u0438\u044f Ginsberg et al., 2006. (* 8)<\/div>\n<p>\u041b\u0438\u0442\u0435\u0440\u0430\u0442\u0443\u0440\u0430:<\/p>\n<ol>\n<li>Rolfs A, B\u00f6ttcher T, Zschiesche M, Morris P, Winchester B, Bauer P, et al. Prevalence of Fabry disease in patients with cryptogenic stroke: a prospective study. Lancet 2005; 366: 1794-1796.<\/li>\n<li>MacDermot KD, Holmes A, Miners AH. Anderson-Fabry disease: clinical manifestations and impact of disease in a cohort of 98 hemizygous males. Journal of Medical Genetics 2001; 38: 750-760.<\/li>\n<li>Beck M. Demographics of FOS &#8212; the Fabry Outcome Survey. In: Mehta A, et al (eds). Fabry disease: perspectives from five years of FOS, 2006; pp. 155-161.<\/li>\n<li>Mehta A, Ginsberg L, on behalf of the FOS Investigators . Natural history of the cerebrovascular complications of Fabry disease Acta Paediatrica 2005; 94 (Suppl. 447): 24-27.<\/li>\n<li>Fellgiebel A, M\u00fcller MJ, Ginsberg L. CNS manifestations of Fabry\u2019s disease. Lancet Neurology 2006; 5: 791-795<\/li>\n<li>Ginsberg L, Valentine A, Mehta A. Fabry disease . Practical Neurology 2005; 5: 110-113.<\/li>\n<li>Moore DF, Scott LTC, Gladwin MT, Altarescu G, Kaneski C, Suzuki K, et al. Regional cerebral hyperperfusion and nitric oxide pathway dysregulation in Fabry disease. Circulation 2001; 104: 1506-1512.<\/li>\n<li>Ginsberg L, Manara R, Valentine AR, Kendall B, Burlina AP. Magnetic resonance imaging changes in Fabry disease. Acta Paediatrica Supplements 2006; 95: 57-62.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u0423\u0441\u0442\u0430\u043d\u043e\u0432\u043b\u0435\u043d\u043e, \u0447\u0442\u043e \u0434\u043e 4,9% \u043c\u0443\u0436\u0447\u0438\u043d \u0438 2,4% \u0436\u0435\u043d\u0449\u0438\u043d \u0432 \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0435 18\u201355 \u043b\u0435\u0442, \u0443 \u043a\u043e\u0442\u043e\u0440\u044b\u0445 \u0440\u0430\u0437\u0432\u0438\u043b\u0441\u044f \u0438\u043d\u0441\u0443\u043b\u044c\u0442 \u043d\u0435\u0443\u0442\u043e\u0447\u043d\u0435\u043d\u043d\u043e\u0433\u043e \u0433\u0435\u043d\u0435\u0437\u0430, \u043d\u0430 \u0441\u0430\u043c\u043e\u043c \u0434\u0435\u043b\u0435 \u043c\u043e\u0433\u043b\u0438 \u0441\u0442\u0440\u0430\u0434\u0430\u0442\u044c \u043d\u0435\u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u0439 \u0431\u043e\u043b\u0435\u0437\u043d\u044c\u044e \u0424\u0430\u0431\u0440\u0438. (* 1) \u0418\u043d\u0441\u0443\u043b\u044c\u0442 \u2013 \u043e\u0434\u043d\u0430 \u0438\u0437 \u043e\u0441\u043d\u043e\u0432\u043d\u044b\u0445 \u043f\u0440\u0438\u0447\u0438\u043d \u0441\u043c\u0435\u0440\u0442\u0438 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0431\u043e\u043b\u0435\u0437\u043d\u044c\u044e \u0424\u0430\u0431\u0440\u0438. (* 2) \u0426\u0435\u0440\u0435\u0431\u0440\u043e\u0432\u0430\u0441\u043a\u0443\u043b\u044f\u0440\u043d\u044b\u0435 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f \u0440\u0430\u0437\u0432\u0438\u0432\u0430\u044e\u0442\u0441\u044f \u0443 \u043c\u0443\u0436\u0447\u0438\u043d \u0432 \u043d\u0430\u0447\u0430\u043b\u0435 3 \u0434\u0435\u043a\u0430\u0434\u044b \u0436\u0438\u0437\u043d\u0438, \u0430 \u0443 \u0436\u0435\u043d\u0449\u0438\u043d \u2013&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"class_list":["post-105","page","type-page","status-publish","hentry","description-off"],"_links":{"self":[{"href":"https:\/\/spiporz.ru\/fabry\/wp-json\/wp\/v2\/pages\/105","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spiporz.ru\/fabry\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/spiporz.ru\/fabry\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/spiporz.ru\/fabry\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/spiporz.ru\/fabry\/wp-json\/wp\/v2\/comments?post=105"}],"version-history":[{"count":1,"href":"https:\/\/spiporz.ru\/fabry\/wp-json\/wp\/v2\/pages\/105\/revisions"}],"predecessor-version":[{"id":107,"href":"https:\/\/spiporz.ru\/fabry\/wp-json\/wp\/v2\/pages\/105\/revisions\/107"}],"wp:attachment":[{"href":"https:\/\/spiporz.ru\/fabry\/wp-json\/wp\/v2\/media?parent=105"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}